The PROBA2 Science Centre (P2SC) is a small-scale science opera- tions centre supporting the Sun observation instruments onboard PROBA2: the EUV imager SWAP and large-yield radiometer LYRA. PROBA2 is one of ESAÕs small, low-cost Projects for On-board Autonomy (PROBA) and part of ESAÕs In-Orbit Technology Demonstration Program. The P2SC is hosted at the Royal Observatory of Belgium, co-located with both Principal Investigator teams. The P2SC tasks cover science planning, instrument commanding, instrument monitoring, data processing, support of outreach activities, and distribution of science data products. PROBA missions aim for a high degree of autonomy at mission and system level, including the science operations centre. The autonomy and flexibility of the P2SC is reached by a set of web-based interfaces allowing the operators as well as the instrument teams to monitor quasi-continuously the status of the operations, allowing a quick reaction to solar events. In addition, several new concepts are implemented at instrument, spacecraft, and ground
segment level allowing a high-degree of flexibility in the operations of the in- struments. We present the key concepts of the P2SC, emphasising the automation and the flexibility achieved in the commanding as well as the data processing chain.